Genetic Evidence Predicts Drug Target Clinical Success
Machine learning analysis of 26,278 drug target-disease pairs, quantifying how strongly genetic evidence predicts successful clinical progression. XGBoost classifier with SHAP interpretability decomposes which types of genetic evidence matter most and for which disease areas.
OR = 3.25 (95% CI 2.79–3.79) · 26,278 pairs · Open Targets + ChEMBL